Keshav and Anjali Kumar, two young siblings from Jharkhand, India suffer from two rare conditions known as Cutis Laxa and Progeria, which make them look incredibly old for their age.

The Indian brother and sister originally made news headlines as the “Benjamin Button siblings” in 2016. Anjali was 7 at the time, and her younger brother was only 18-months-old, but they both already looked like octogenarians. And not only was their skin unusually wrinkly and saggy, but they both suffered from joint pain associated with old age. This paradoxical situation earned them the nickname ‘Benjamin Button siblings,’ after the fictional character in F. Scott Fitzgerald’s short story. Keshav and Anjali Kumar were diagnosed with progeria and cutis laxa, two exceptionally rare conditions that are, unfortunately, incurable.

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Hu Juan, a 28-year-old mother of two from Hunan, China, suffers from a rare condition known as Cutis laxa which has caused the skin on her face and neck to age at an accelerated rate, leaving her looking like a woman in her 60s or 70s.

The young woman’s nightmare began 11 years ago, right after she gave birth to her eldest son. She started noticing that her appearance was changing fast and just six months after giving birth, her youthful looks had deteriorated drastically to the point where she could hardly recognize herself in the mirror. Hu Juan was diagnosed with Cutis laxa, an extremely rare connective tissue disorder that causes the skin to become loose, saggy and wrinkled at a very rapid speed due to loss of elasticity. It has only affected her face and neck, and several medical checkups over the years revealed that she is otherwise  in good health. Hu Juan is the only known Cutis laxa sufferer in China and one of ten worldwide. Read More »