The Lazarus Drug – A Sleeping Pill That Can Temporarily Fix Severe Brain Damage

Zolpidem is a sedative from the imidazopyridine class of drugs that is most commonly used to help people fall asleep faster. But, in rare cases, this common drug can actually restore function to damaged brains.

There is a reason why zolpidem is sometimes referred to as the “Lazarus Drug”. If you give this pill to someone with brain damage, in 5% to 6% of cases something miraculous happens. In most cases, the changes are minor. People’s speech improves slightly, the frequency of muscle spasms is reduced, they have less difficulty moving, but in some rare cases, a pill can even bring people back from vegetative states, allowing them speak and move as they did before suffering brain damage. The problem is that these positive effects are gone as soon as the drug wears off, and scientists have yet to discover why some patients with brain damage react this way to zolpidem.

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