Hemgenix, a single-dose cure for a form of the blood-clotting disorder hemophilia, recently set a new world record for the most expensive drug ever at a whopping $3.5 million per dose.

On Tuesday, The US Food and Drug Administration approved Hemgenix, a cutting-edge gene therapy designed to treat adults with hemophilia B, a serious genetic disorder in which people do not produce a critical protein needed to clot blood in case of bleeding. Until now, typical treatments required routine injections to maintain sufficient levels of the missing protein in patients, but thanks to Hemgenix, sufferers of hemophilia B require a single IV infusion to be cured forever. The only problem is that that single dose costs no less than $3.5 million, making Hemgenix the most expensive drug ever.

Read More »

Honeypot Ants, or honey ants, are specialized workers of several species of ants whose sole job is to gorge on nectar until they become living honey-storage.

Did you know that honeybees aren’t the only insects capable of producing the sweet, viscous, and brown-to-golden-colored natural product we know as honey? Several other species of bees, as well as bumblebees and even wasps are known to produce the sugary treat, but perhaps the most unusual insect able to convert nectar into honey is the honeypot ant. Belonging to a number of ant species, the most common of which is Camponotus inflatus, honeypot ants are specialized workers that act as living storage for their colonies when food is scarce.

Read More »

Argentina is known for a lot of things, from tango to its love of football, but you probably didn’t know that it’s also home to the world’s drunkest drivers.

Back in March of this year, Argentinian media reported that a young man in the town of Plottier, Neuquén province, had broken the world breathalyzer record, after scoring an unprecedented 5,79 grams of alcohol per liter of breath when tested by police, after crashing his car in a ditch. Despite suffering minor injuries to his face and arms because of the crash, he refused medical assistance and did not cooperate with the police. However, he would not get to brag about his unusual record for too long, because just last week, a fellow Argentinian broke it again.

Read More »

Hum is a picturesque hilltop settlement in Croatia’s Istria region whose main call to fame is being the smallest town in the world.

Located in central Istria, approximately a 2.5 hours drive from Croatia’s capital city of Zagreb, the medieval hilltop town of Hum is home to between 20 and 30 people (21 according to the 2011 national census, and 27 as of 2021). Its origins are shrouded in mystery, but its first mention in historical documents dates back to the year 1102, when it was called Cholm. A bell and watch tower was built in 1552 as part of the town’s defenses, and guards and their families started moving in, but the town never really developed over the centuries, and even today it consists of just three neat rows of medieval houses and two streets.

Read More »

Often weighing in at more than 10 kilograms (22 lbs), the Flemish Giant is by far the largest rabbit breed in the world. They are also extremely docile creatures and make great pets.

Originally a utility breed raised in Flanders, Belgium for its fur and meat, the Flemish Giant eventually became a show breed, due to its high bone-to-meat ratio. Today, they are considered one of the most docile and tolerant rabbit breeds in the world and can make great pets, if raised correctly. According to breed standards, a well-developed Flemish Giant has a large head, long, erect ears, a long and powerful body, and a nicely rounded rump. Unsurprisingly, the world’s largest rabbit is a Flemish Giant rabbit that weighs 49 lb (22 kg) and measures 1.3 m (4 ft 3 in).

Read More »

The Isles of Scilly Football League is the world’s smallest official football league, consisting of only two teams that play each other seventeen times a season.

As the home of football, England has always been crazy about the team sport, and the Isles of Scilly, an archipelago of more than 140 islands off the southwestern tip of Cornwall, is no exception. Like many other regions of England, the isles have their own football league, but what sets them apart is the size of the league – it consists of just two teams, the Garrison Gunners and the Woolpack Wanderers, that play each other every weekend during a season, as well as in two yearly cups and the traditional ‘Old Men versus the Youngsters’ game played on Boxing Day.

Read More »

To celebrate the 175th anniversary of Switzerland’s first railway, a railway company created the world’s longest passenger train ever, a 1.2-mile-long monster snaking through the Swiss Alps.

Switzerland’s mountain railways are regarded as feats of engineering, but they are hardly the best place to attempt a world record for the world’s longest passenger train. And that goes double for Rhaetische Bahn railways. Not only is the alpine terrain itself a challenge, featuring sharp turns and constant gradient changes, but the railway itself is considerably narrower –  just one meter apart, compared to the standard 1.435 meters. In order for the 25 “Capricorn” electric trains (a total of 100 passenger cars) to complete their voyage successfully on the UNESCO World Heritage Albula Line from Preda to Alvaneu in eastern Switzerland, everything had to be perfect.

Read More »

IV therapy is usually associated with curing illnesses, but when it comes to creating the world’s most expensive wood, IV drips are a means of delivering poison.

About a week ago, a couple of photos showing large IV drips filled with a dubious-looking liquid hanging from trees went viral on Chinese social media, prompting all kinds of reactions from people. Some wondered if it was an art installation designed to raise awareness about the rampant deforestation taking place on a global scale, or about the human-made pollution killing plant life, while others were convinced that it was a genuine treatment method designed to save the trees from fungi or other parasites. There were even those who said it was vandalism, that the bags were filled with human urine. All of these theories turned out to be wrong.

Read More »

TinyCircuits, a hardware company specializing in creating tiny electronic devices, recently unveiled the world’s smallest television sets.

When it comes to modern TVs, the general consensus is that bigger is better, but one company is trying to prove that it can be successful by going against the trend. TinyCircuits, an open-source hardware company that makes all sorts of tiny electronic devices, has created the world’s smallest television sets – the TinyTV 2 and TinyTV Mini. While these retro-looking devices may be the size of postage stamps, they actually work about as well as regular-size TVs, featuring channel and volume-adjusting knobs, remote control, 8Gb of storage, and PC connectivity for uploading videos.

Read More »

A Pittsburgh-based robotics and engineering startup recently unveiled Moonwalkers, a pair of battery-powered shoes that it claims can boost walk speeds by up to 250%.

At first glance, Moonwalkers look like a pair of futuristic rollerskates, but there is actually a lot more to them than that. You’re actually meant to walk with them the way you would regular shoes or sneakers, letting the motorized wheels put a spring in your step. Powered by a state-of-the-art brushless DC motor, this ingenious contraption is actually a platform that can be attached to a wide variety of footwear to significantly increase your walking speed up to a reported 7mph/11kph. For comparison, humans’ average walking speed ranges from 2.5 to 4 mph. The sensation of walking with the world’s fastest shoes has been compared to that of walking on a ‘moving walkway’ in an airport.

Read More »

An archery master recently set a new Guinness Record by shooting seven consecutive arrows through a tiny keyhole using a traditional Ottoman bow.

Lars Andersen is often hailed as the world’s ultimate archer, performing feats that most us mere mortals can only dream about. He is the only person capable of shooting 10 arrows in just 4.9 seconds, he can shoot arrows that turn in mid-flight, and shoot while holding multiple arrows in his draw hand. Recently, Andersen added another feather to his already impressive cap by shooting seven consecutive arrows through a keyhole less than 10mm in size, thus setting a new Guinness record.

Read More »

In 1994, a man was involved in a serious car accident that should have left him with at least a few broken bones. But he suffered no fractures at all, because he had the densest, strongest bones anyone had ever seen.

When doctors looked at the X-rays of the man involved in the car accident – his name was never disclosed to the public – not only did they notice no fracture, but also that his bones seem to be unusually dense, eight times denser than normal, to be precise. This was unlike anything they had ever seen or even heard of before, so they referred the man to Karl Insogna, the director of the Yale Bone Center. Insogna performed additional tests, but after failing to discover a cause for this unusual bone density or any negative effects associated with it, he sent the man on his way. As fate would have it, a few years later, the researcher would come across a few people with similarly dense bones, which turned out to be distantly related to that remarkable man he’d examined…

Read More »

A 33-year-old gorilla who has spent most of her life alone inside a metal cage on the seventh floor of a shopping mall in Bangkok, Thailand, has been dubbed the world’s loneliest gorilla.

Bua Noi was only one when she was put into the cage that would become her permanent home for more than three decades. She was one of the main attractions of a bizarre zoo – if one could even call it that – inside Bangkok’s oldest shopping mall, Pata Pinklao Department Store, and owners refused to relocate her to a more suitable location, despite numerous requests from animal rights activists and the Thai Government. Even today, Bua Noi’s owners refuse to let her live out the rest of her days in a sanctuary, with other members of her species.

Read More »

Located on a hill in the heart of Rome and featuring the only ceiling mural ever painted by the Italian Baroque old master Caravaggio, Villa Aurora is widely regarded as the world’s most expensive house.

The 30,000-square-foot, 16th-century villa is located a short walk from the famous Via Veneto, home to some of Rome’s best hotels, and close to the iconic Piazza di Spagna and the ancient Porta Pinciana. Originally a hunting lodge, the villa is all that remains of a 30-hectare complex owned by Italy’s Ludovisi noble family, who gave the country numerous diplomats, patrons of the arts, and even a Pope. Today, Villa Aurora finds itself at the heart of a legal battle and an Italian court has ruled that it should be sold at auction. Only the price set for the property is so high that no one seems interested in paying it.

Read More »

Kitti’s hog-nosed bat, also known as the Bumblebee Bat, is not only the world’s smallest bat, but also arguably the smallest mammal in the known world.

Our world is home to over 1,200 species of bats, but the smallest of them all can only be found in a few caves in Thailand and Myanmar. The aptly-named Bumblebee Bat is so tiny that it can rest comfortably on an average-size human finger. Its size ranges from 29 to 33 mm, and it only weighs 2 grams. The wingspan of the Bumblebee bat is 170 mm.

Discovered in 1973, by Thai biologist, Kitti Thonglongya, who also gave the species its official name, the Bumblebee Bat has since become a popular tourist attraction in both Western Thailand – with roosts identified in 44 limestone caves – and Myanmar, where it is known to inhabit 5 caves.

  Read More »